HV is a SPM toolbox fully integrated into the SPM8 GUI to calculate hippocampal volumes based on 3D MPRAGE images.

The methodology and pertinent applications are described in the following manuscripts:

Suppa P, Anker U, Spies L, Bopp I, Rüegger-Frey B, Klaghofer R, Gocke C, Hampel H, Beck S and Buchert R (2015) Fully automated atlas-based hippocampal volumetry for detection of Alzheimer’s disease in a memory clinic setting. J Alzheimers Dis 44:183–193.

Suppa P, Hampel H, Spies L, Fiebach J, Dubois B and Buchert R (2015) Fully automated atlas-based hippocampal volumetry for clinical routine: validation in subjects with mild cognitive impairment from the ADNI cohort. J Alzheimers Dis 46:199–209.

The HV toolbox is free but copyright software, distributed under the terms of the GNU General Public Licence as published by the Free Software Foundation. Further details on "copyleft" can be found under

This toolbox comes with absolutely NO WARRANTY! It is especially not intended for any clinical or diagnostic use.

If you want to use HV for diagnostic and clincal use, professional services can be provided via jung diagnostics GmbH. Please send an email to service [at] jung-diagnostics [dot] de.

The HV toolbox can be downloaded here.

jung diagnostics GmbH

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